Semaglutide Dosage Chart Explained: Weekly Injections by Weight Loss Stage

For many adults exploring GLP-1 treatments, understanding how weekly injections are scheduled is just as important as knowing the medication works. A semaglutide dosage chart lays out this progression clearly—breaking the process into staged, weight loss-focused phases: initiation, escalation, and maintenance. But if you’re wondering what those numbers actually mean for your personal journey, you’re not alone. Let’s walk through the typical breakdown, what to expect in each stage, and how your provider might personalize your plan.

How Weekly Semaglutide Injections Begin (Initiation Phase)

Whether you’re prescribed a brand-name version or compounded semaglutide, your starting point is almost always the same: a low-dose introduction phase. This is designed not for results, but for acclimation. Most regimens begin with 0.25 mg subcutaneously once per week for the first four weeks.

At this stage, the primary goal is to give your body time to adjust. People may not see substantial physical changes yet, but some do report early appetite reduction. It’s common for patients to feel slightly underwhelmed during this initial phase—but it’s a critical foundation to reduce side effects later during dose increases.

Stepwise Increases: The Escalation Phase Explained

The next few months involve a gradual step-up in dosing. This is where you begin moving through the tiers of the semaglutide weight loss dosage chart. Here’s a general progression that clinics commonly follow:

• Weeks 5–8: 0.5 mg weekly
• Weeks 9–12: 1 mg weekly
• Weeks 13–16: 1.7 mg weekly

This stage is all about ramping up the medication’s metabolic impact without triggering intense nausea or other GI symptoms. If side effects emerge at any point, your provider may pause the increase or temporarily dial back your dose. The flexibility of escalation is one reason many individuals opt for a compounded semaglutide dosage chart—especially when customized dosing options are preferred.

What the Maintenance Dose Looks Like—and Why It Matters

After around four months of dose titration, most protocols aim for a semaglutide maintenance dose for weight loss of 2.4 mg per week. This is typically when appetite suppression, fat loss, and blood sugar benefits stabilize. Patients are often surprised to learn that this dose isn’t universally necessary—some continue to see success at 1.7 mg, while others feel better staying at 1 mg due to tolerability.

Consistency is key at this stage. Whether you’re using Wegovy, compounded injectables, or another GLP-1 formulation, the focus shifts from “increasing” to “sustaining.” Your provider may reassess your dose every 8 to 12 weeks depending on progress.

What If You Can’t Tolerate the Target Dose?

One of the most common questions is: “What happens if I can’t stay at 2.4 mg?” The answer depends on how your body responds. Some patients temporarily reduce back to 1.7 mg to give their system time to catch up. This dose can be held for up to four weeks before reattempting an increase. If symptoms persist, your provider may opt to keep you at the highest comfortable level rather than discontinue use.

This personalization is why a semaglutide dosing chart is better viewed as a roadmap, not a rulebook. Adjustments don’t mean failure—they mean you’re working with your biology instead of against it.

Using a Semaglutide Dosage Calculator: Is It Helpful?

Online semaglutide dosage calculators can be useful tools for visualizing progress over time. They estimate your ideal weight loss trajectory based on dosage stage and BMI. However, these calculators don’t replace clinical guidance. Factors like tolerance, lifestyle, coexisting conditions, and even hormonal balance all influence the optimal dosing pace.

Think of these tools as directional, not diagnostic. Your real results—and how much weight you may lose—will depend on the total picture, not just the milligram count.

How Much Weight Can You Lose on Semaglutide in 3 Months?

Results vary, but clinical studies and real-world data show that many individuals lose 5% to 10% of their body weight by the 12-week mark—especially if they reach at least the 1 mg or 1.7 mg dose by that point. Some see faster drops in the first few months due to reduced cravings and smaller portion sizes, while others notice a slower, steady curve.

Your rate of weight reduction will depend on dietary choices, physical activity, dosage consistency, and whether you’ve reached your personal maintenance dose yet.

How to Use Semaglutide for Weight Loss Safely

Injection technique, timing, and site rotation all matter. For subcutaneous delivery, most inject into the thigh, abdomen, or upper arm. It’s recommended to rotate locations weekly to avoid irritation. Doses are given once per week, ideally on the same day and time.

If a dose is missed and your next scheduled injection is more than two days away, you can administer the missed dose late. But if it’s closer than 48 hours, skip it and continue as planned the following week. This helps prevent stacking and reduces the risk of side effects.

Adjustments for Special Situations

Although the drug’s labeling indicates no changes are required for those with liver or kidney issues, providers may still monitor these patients more closely. Additionally, if you’re taking insulin or medications that stimulate insulin secretion, your overall regimen may need adjustment to reduce the risk of low blood sugar.

Always discuss these factors during follow-ups to avoid underdosing—or overdosing—accidentally.

Summary: Stages of the Semaglutide Dosage Timeline

The standard semaglutide dosage chart for weight loss breaks into three phases:

1. Introduction (Weeks 1–4): 0.25 mg
2. Escalation (Weeks 5–16): Gradually increasing from 0.5 mg to 1.7 mg
3. Maintenance (Week 17+): Target of 2.4 mg or highest tolerable dose

Each stage builds on the previous one with the goal of steady fat reduction and metabolic balance. Whether you’re early in your GLP-1 journey or approaching long-term treatment, understanding these stages can help you stay informed and in control of your progress.

Final Thought: Before relying on any online chart or calculator, speak with a qualified provider familiar with semaglutide for weight loss. Personalized care matters more than numbers on a PDF. Every body is different—and the best weight loss plans respect that.